Oral squamous cell carcinoma in patients with Fanconi anemia: A case series
نویسندگان
چکیده
Introduction: Fanconi anemia (FA) is a rare inherited disorder characterized by progressive bone marrow failure, congenital malformations and increased susceptibility to malignancies particularly acute myeloid leukemia and solid tumors such as head and neck, gastrointestinal and genitourinary tract carcinomas. the squamous cell carcinoma of the head and neck (HNscc), known for its aggressive growth capacity, multifocal origin and propensity to metastasize is the most frequent solid tumor in these patients and is frequently associated with poor prognosis. An increased understanding of Fanconi anemia associated with malignancies is important in the clinical management of these patients and can elucidate the role of the disease in the development of malignant tumors namely head and neck squamous cell carcinoma. case S. Goncalves1, Montgomery-Cranny J.1, Hunter K.D.2, A. Yousefpour3, L. Durham4, A.M. Hegarty1 Affiliations: 1Department of Oral Medicine, Charles Clifford Dental Hospital, 76 Wellesley Road, S10 2SZ Sheffield, United Kingdom; 2Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, S10 2TA Sheffield, United Kingdom; 3Department of Oral and Maxillofacial Surgery, Charles Clifford Dental Hospital, 76 Wellesley Road, S10 2SZ Sheffield, United Kingdom; 4ENT Department, Royal Hallamshire Hospital, Glossop Road, S10 2JF Sheffield, United Kingdom. Corresponding Author: Dr. Anne Hegarty, Department of Oral Medicine, Charles Clifford Dental Hospital, Wellesley Road, Sheffield S102SZ; Email: [email protected] Received: 02 May 2016 Accepted: 06 June 2016 Published: 30 June 2016 series: We describe three unrelated cases of patients with FA and multifocal head and neck squamous cell carcinomas. conclusion: this study highlights the susceptibility of patients with Fanconi anemia to malignant tumor development and reinforces the need for a routine head and neck cancer screening. the reader should understand the clinical features, implications of this association and the appropriate management of patients with Fanconi anemia.
منابع مشابه
Salivary Antioxidant Level in Oral Squamous Cell Carcinoma
Background: Oral cancer is among the 10 most common cancers worldwide with an increasing global incidence. Compromised antioxidant defense system plays a role in occurrence of cancer. This study evaluated the salivary antioxidant level of oral cancer patients compared to a control group. Patients and Methods: This case-control study was conducted on 22 oral squamous cell carcinoma patients pre...
متن کاملUnusual presentation of primary mandibular gingival squamous cell carcinoma in young male: A case report
BACKGROUND AND AIM: Squamous cell carcinoma (SCC) is usually considered a disease of older people. Recently, there is a change in the occurrence of such lesions in young patients and lacking the established risk factors. CASE REPORT: A 21-year-old male reported with an innocuous gingival growth over lower incisors since a month. Within 15 days he noticed another gingival growth in same region l...
متن کاملNoninvasive molecular screening for oral precancer in Fanconi anemia patients.
LOH at chromosome arms 3p, 9p, 11q, and 17p are well-established oncogenetic aberrations in oral precancerous lesions and promising biomarkers to monitor the development of oral cancer. Noninvasive LOH screening of brushed oral cells is a preferable method for precancer detection in patients at increased risk for head and neck squamous cell carcinoma (HNSCC), such as patients with Fanconi anemi...
متن کاملFanconi anemia manifesting as a squamous cell carcinoma of the hard palate: a case report
Fanconi anemia is a rare autosomal recessive disorder characterized by various congenital malformations, progressive bone marrow failure at a very young age and of solid tumors development. The authors present a rare case of a squamous cell carcinoma of the hard palate in a Fanconi Anaemia patient. The atypical clinical manifestation rendered the diagnosis more difficult. This case, for age of ...
متن کاملEvaluation of clinical and histological parameters in patients with oral squamous cell carcinoma referred to Tehran Faculty of Dentistry (1966 – 2002)
Evaluation of clinical and histological parameters in patients with oral squamous cell carcinoma referred to Tehran Faculty of Dentistry (1966 – 2002) Dr. N. Eshghyar* - Dr. P. Motahari** - Dr. A. Khorshidian*** *- Associate Professor of Oral & Maxillofacial Pathology Dept.- Faculty of Dentistry-Tehran University of Medical Sciences. **-Assistant Professor of Oral & Maxillofacial Pathology Dept...
متن کامل